Thermostability is a protein property that impacts many types of studies, including protein activity enhancement, protein structure determination, and drug development.However, most computational tools designed to predict protein thermostability require tertiary structure data as input.The few tools that are dependent only on the primary structure
The TSH receptor (TSHR) comprises an extracellular leucine-rich domain (LRD) linked by a hinge region to the transmembrane domain (TMD).Insight into the orientation of these components to each other is required for understanding how ligands activate the receptor.We previously identified residue E251 at the LRD-hinge junction as contributing Socks t
There is a growing K2 recognition by city policymakers that urban public transport systems can be developed in such a way that travelers can be offered an alternative to car-based travel.How to evolve the public transport system for this purpose is a significant challenge and raises questions of accessibility and quality largely absent from current